Safety System

Aggressive attack on disease requires equally careful patient safety considerations. Our therapy has a built-in safety system, which can be triggered to eliminate the genetically-modified cells by administering AZT to the patient

Publications

Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA. Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis.
Methods in Molecular Biology 1317:55-67 (2015).

Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA. The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.
PLoS ONE 8(10):e78711 (2013).

Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA. Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy.
Molecular Therapy: J. American Society Gene Therapy. 15(5):962-70 (2007).